Drug discovery seminar

Dear class,

The Technology Management Program has a seminar next week from Roger Perlmutter, the Executive Vice President of Research and Development at Amgen. The title of the talk is "Building Better Medicines: Drug Discovery in the 21st Century" and it may be of interest to many of you who are thinking about careers in biotechnology and medicine. I imagine that you will be well-equipped to understand the content of the talk with what we've discussed in class so far.

http://www.tmp.ucsb.edu/outreach/pdf/LSPoster_Perlmutter_HR.pdf

Cheers,
MSS

HW1 solutions

Dear class-

The solutions to HW1 are now posted on the course website.

Cheers,
MSS

HW 1 pickup

Hi everyone,

If you would like to pick up your graded first homework before Thursday class, I will be available in my office (Chemistry 3219) from 3-5 PM tomorrow (Wednesday).

Sunyia

Problem 5 on HW2

Dear class,

At some point in this problem it asks you to prove that DeltaS(Ts) = 0. One approach would be to go back to the derivation for the free energy of folding with temperature that you did in HW1, where you had explicit expressions for DeltaS and DeltaH. Another approach might be to use a thermodynamic identity that you learned in your ChE110 classes. Hint: if you know G(T,P) then what is (dG/dT)_P, by definition?

Cheers,
MSS

Question

I was reading my Biochem book and it states that a closed system exchanges energy, but not matter. I though you said the opposite in class. Also, for today's lecture, I was confused on where the lecture is taking us. Are we studying the probability of empty sites that will later translate to sites on enzymes or some other typing of bonding in the cell?

Closed systems are those that can exchange energy, but not mass. Isolated systems are those that exchange neither.

The example worked in class was just a simple case to illustrate the properties of Boltzmann probabilities. We will not connect this specific example to any biomolecular process; however, the final, general equations that we arrived at, namely the connection between state probabilities and free energies, will be used quite extensively.